Cavernous Malformation Research

Cerebral Cavernous Malformation: What a Practicing Clinician Should Know by Kelly D. Flemming and Giuseppe Lanzino (2020)

Overview: An overview of CCMs, covering epidemiology, clinical presentation, diagnosis via MRI, management strategies including observation, surgery, and medical treatment, and the prognosis of these vascular brain lesions.

Female Hormone Therapy and Risk of Intracranial Hemorrhage From Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study by Susanna Zuurbier et al (2023)

Overview: Female hormone therapy (oral contraception in female patients of reproductive age and menopausal hormone therapy in postmenopausal patients) is not withheld from patients with cerebral cavernous malformations (CCMs), although the effects of these drugs on the risk of intracranial hemorrhage are unknown. This study investigated the association between female hormone therapy and intracranial hemorrhage in female patients with CCM in 2 large prospective, multicenter, observational cohort studies. 

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CS3R1-CX3CL1 Signaling by Eduardo Firas-Anaya et al (2024)

Overview: This study finds that mild hypoxia accelerates CCM disease by promoting angiogenesis, neuroinflammation, and vascular thrombosis in the brains of CCM mouse models. 

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease by Romuald Girard et al (2016)

Overview: Having lower vitamin D and non-HDL cholesterol levels were linked to increased severity in CCM, suggesting these biomarkers correlate with early symptoms and hemorrhages in CCM patients.

Familial Cerebral Cavernous Malformations by Kelly D. Flemming et al (2023)

Overview: This study discusses familial  cerebral cavernous malformations; covering genetics, symptoms, diagnosis, and management. 

Current and Future Treatment Options for Cerebral Cavernous Malformation by Leslie Morrison et al (2024)

Overview: This study discusses existing and potential future treatments of cerebral cavernous malformation, focusing on both surgical and emerging pharmacological approaches. 

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation by Ying Li et al (2023)

Overview: This study explores how inflammation may contribute to cerebral cavernous malformation, exploring the molecular and cellular mechanisms involved.